吴剑胜，男，主任医师，心内科副主任，介入心脏病专科主任，胸痛中心总监。广东省医师协会心脏介入分会委员，广东省胸痛中心协会理事，中国胸痛中心培训讲师，中国胸痛中心认证专家，美国范德堡大学医学中心访问学者。

魏文斌，男，心内科副主任、血管病与结构性心脏病主任、主任医师。参与制定卵圆孔未闭规范化诊疗中国专家共识，主持包括市科创委、区重点项目等基金，主持ELASO临床研究项目，作为分中心PI参与包括SPRINT研究在内的多中心临床研究，以第一/通讯作者发表SCI论文4篇，每年在省级、国家级学术大会进行学术授课多次。

学术任职：中国老年医学学会周围血管疾病分会常务委员、广东省健康管理学会肺血管病专业委员会副主任委员，广东省中西医结合学会心血管病委员会常务委员、广东省医师协会老年病分会常务委员、深圳市医师协会结构性心脏病专业委员会副主任委员

业务专长：熟练掌握外周血管疾病、肺动脉高压、冠心病的诊治，率先开展深圳首例经皮肺动脉腔内成形术、颈内静脉径路心内膜下心肌活检，擅长深静脉血栓、外周动脉闭塞疾病、肺血管病、冠心病的介入治疗。

医学博士，主任医师，博士研究生导师，主持国家自然科学基金面上项目、四川省重点研发计划、四川省科技支撑计划、国家老年病中心项目等在内的各级科研项目10余项，发表论文60 余篇，SCI收录30余篇。国家发明专利8项，实用新型专利2项。

擅长骨质疏松性高龄老人并存心、肺、肾脏病症、糖尿病、高血压患者的髋部骨折的治疗、复杂的骨盆及髋臼骨折的治疗、复杂的髋、膝周围骨折的治疗、骨折不愈合、畸形愈合、内固定术后断裂、内固定术后感染的治疗、足踝部骨折和足踝部创伤后遗症以及足踝疾病的临床诊断及治疗等常见及高难度创伤骨科疾病的治疗。

 

学术任职：

中国医师协会骨科学分会足踝外科工作委员会副主任委员

中华医学会四川省骨科学分会创伤学组委员

中国研究型医院学会骨与关节感染工作委员会副主任委员

骨科创新与转化专业委员会常委

中国外固定协会常务委员

四川省中西医结合协会常务委员

医学博士，主任医师，博士研究生导师，来自301医院的广东省特殊引进人才。创建北大深圳医院运动医学与康复中心并任主任，现任中大八院运动医学科主任。发明“关节镜下臀肌挛缩松解手术”、改进“半月板移植”、“椭圆骨道前交叉韧带重建”等。独创“肩胛下肌捆绑治疗肩脱位”入选2019运动医学最佳技术进步。译著多部并发表SCI 50余篇，专利20余项。

学术任职：
国家“863”项目子课题负责人
曾任广东医师运动医学副主委及中华骨科关节镜全国委员
中国医师骨科运动医学分会委员
中国运动医疗分会下肢组委员

医学博士，中山大学博士生导师，中山大学医学院外科教研室副主任，中山大学附属第八医院骨科副主任，骨肿瘤专科负责任人。

擅长骨与软组织肿瘤、骨质疏松症等骨科疾患的精准诊断与治疗，针对骨肉瘤、骨巨细胞瘤等原发骨肿瘤、脊柱肿瘤和脊柱四肢骨转移瘤开展手术和综合治疗，开展脊柱肿瘤全脊椎切除术等高难度手术，并率先开展微创术中放疗治疗恶性肿瘤和骨转移瘤。教学荣获中山大学教学成果一等奖3项，全国大学生技能竞赛特等奖优秀教官，技能培训特聘教官，教学比赛一等奖等多种奖励，主持教改研究多项。科学研究获得国自然科学基金立项1项，已发表多篇临床、科研及教学文章。

主要学术任职：

广东省医师协会脊柱外科分会 常委

广东省医学会骨科学分会 委员

广东省临床医学会肿瘤学专科联盟第一届副理事长

广东省抗癌协会肿瘤转移委员会 委员

广东省医学会骨科学分会智能学组 委员

广东省骨质疏松学会 委员

深圳市医师协会骨科医师分会 常务理事

张慧东，中山大学研究员，博士生导师，中山大学附属第八医院医学研究中心 副主任。曾入选/获得海外高层次人才项目（青年项目）（2014）、自然科学基金委优秀青年科学基金（2015）、辽宁省科技奖励一等奖（2015）、中国毒理学会优秀青年科技奖（2016）、四川省卫计委领军人才（2017）、四川省特聘专家（2017）、四川大学青年科技人才奖（2017）、四川省卫健委学术技术带头人（2018）、四川省专家评议（审）委员会（2020）、四川省学术技术带头人（2020）、中山大学高层次人才计划中青年杰出人才（2021）、深圳市高层次专业人才（2021）等。

围绕“环境和女性生殖健康”主题，长期探索环境因素引发不明病因流产的新途径和新机制，并探索相应的干预措施，在面上（3项）、优青、科技部重点专项、高层次人才计划等25项基金的资助下，以第一或通讯作者（含共同）在Nucleic Acids Res (2018, 2020)、Autophagy (2024)、Adv Sci (2024)、Redox Biology (2024)、ACS Nano (2024)、Environ Health Persp (2023)、Part Fibre Toxicol (2024)、Environ Int (2023, 2024a, 2024b)、J Hazard Mater (2024a, 2024b, 2023)、Proc Natl Acad Sci USA (2011)、Sci Total Environ (2021)、J Biol Chem (2016, 2012a, 2012b, 2009a, 2009b, 2009c)等国际知名杂志上发表SCI论文87篇，发表中文核心期刊论文9篇；被Science、Nat Commun、Ann Rev Biochem、PNAS等国际著名期刊正面评价及引用1261次（至2023.02.09, Web of Science）。

受Springer出版社邀请独立撰写关于“DNA Replication-Damage from Environmental Carcinogens”的Briefs（2015）。于本领域国际著名杂志Mutat Res Rev、Crit Rev Biochem Mol和Crit Rev Toxicol上，综述本团队最新的研究进展以及国际热点（2016，2020，2022，2023）。受邀Genes杂志邀请，撰写DNA replication control的专刊（2017）。受《环境和职业医学》杂志邀请组稿“环境和女性生殖健康”的专刊（2019）。受Springer Nature出版社邀请作为主编出版PubMed收录的“Environment and Female Reproductive Health”英文丛书，Advances in Experimental Medicine and Biology 1300 (IF: 2.450; 2021)。受Genome Instability & Disease杂志邀请，撰写缺氧和女性不良妊娠结局的综述专刊（2022）。研究成果以独立通讯作者发表在环境健康领域的国际权威期刊Environ. Health Persp.上，并被该杂志推荐为Science Selection（2023）。

受邀参加6th International Conference on Biomedical and Environmental Sciences & Technology (icBEST-2016)和7th international symposium on DNA Damage Response & Human Disease (isDDRHD-2016)的国际研讨会、第四届毒性测试替代方法与转化毒理学（国际）学术研讨会（2018），并做口头报告。受邀参加中国毒理学会议（2017、2019），中国诱变剂学术会议（2017、2019、2023、2024）、全国环境与健康学术会议（2018、2019、2020、2021、2023、2024）、全国卫生检验学术交流大会（2021）、第三届全国母胎医学大会（2021、2023）、第十一届环境化学大会（2021），并做口头或主旨报告。受邀担任中国环境诱变剂学会会议（2022）和第四届全国生殖健康专业委员会年会（2022）分会场主持。负责组织并筹办基因不稳定与疾病防治高峰论坛（2016，重庆）和第三届全国现代生物物理方法与技术暨国际单分子生物学研讨会（2020，成都）。

已指导多项大学生创新创业训练计划（包括国家级2项）和本科毕业论文；已培养（含联培）7名博后（出站4+在站3）、14名博士（毕业11+在读3）和61名硕士（毕业43+在读8）。参编全国高等学校教材人卫版《毒理学》第二版，并获选广西省普通本科高校优秀教材；参编全国高等学校医学研究生规划教材人卫版《分子毒理学》第一版和第二版。

担任中华预防医学会卫生毒理学专委会、中国诱变剂学会青年委员会、中国康复医学会生殖健康专业委员会、中华预防医学会卫生检验委员会、中国生物化学和分子生物学酶学委员会等12个国家一级或二级专委会的委员或常务委员。担任《环境与职业医学》杂志常务编委。担任国家基金委自然科学基金、国家科技部重点研发计划重点专项、国家科技奖励的评审专家；担任波兰国家科学中心和重庆市、四川省、江苏省、河北省、广东省和贵州省科技项目评审专家；担任广东省科学技术奖评审专家；担任教育部学位与研究生教育发展中心学科评估专家（第四、五轮）；担任高等学校科学研究优秀成果奖（科学技术）、教育部学位中心博士硕士学位论文、国家留学基金委公派研究生项目评审专家。担任香山科学会议评审专家。担任Nucleic Acids Res、Environ Health Persp、Environ Int、Sci Total Environ、Toxicol Sci等16个国际知名杂志的审稿人。担任J Hazard Mater、Sci Total Environ等杂志的编委。

集中于“环境和女性生殖健康”，探索新污染物引发不明病因流产的新途径和新机制，构建不明病因流产的病例-对照研究队列，探索环境污染物和流产的相关性；构建染毒动物模型，探索环境污染物引发流产的因果性；在细胞学上探索流产的发病机制，揭示非编码RNA在其中的作用和调控机制；再回到组织和动物，探索女性不明病因流产的早期诊断标志物和干预途径；为不明病因流产的诊断和治疗提供重要的科学基础，保障我国生育力。

2021.05，入选深圳市高层次专业人才（地方级）

2021.01，入选中山大学“高层次人才计划”中青年杰出人才

2020.12，入选第十三批四川省学术技术带头人

2020.06，入选四川省专家评议（审）委员会

2018.12，入选四川省卫生健康委学术技术带头人

2018.04，获2017年度四川大学青年科技人才奖

2018.01，入选四川省青年高层次人才计划

2018.01，获四川省卫生计生委领军人才

2016.08，获中国毒理学会优秀青年科技奖

2015.12，获辽宁省科学技术奖励一等奖，纳米空间中的多相手性催化研究

2015.01，获国家自然科学基金委国家优秀青年科学基金资助

2014.01，入选中组部第十一批国家“高层次人才计划”(青年项目）

发表论文 (截至2024.10.22)

[2024]

102. BaP/BPDE suppresses homologous recombination repair in human trophoblast cells to induce miscarriage: the roles of lnc-HZ08.  Weina Chen#, Chenglong Ma#, Manli Wang#, Xinying Huang#, Xueyu Chen, Zhongyan Xu, Wenxin Huang, Rong Wang, Zhaodian Zheng, Jing Fang, Yanqiu Shen, Depeng Zhao*, and Huidong Zhang*. Environ. Int., 2024, 191, 108975.  (Invited special issues) (0160-4120; Q1; IF: 11.8; cited by 2 times; 中科院环境科学一区).   

101. Structural basis for linker histone H5-nucleosome binding and chromatin fiber compaction.  Wenyan Li; Jie Hu; Feng Song; Juan Yu; Xin Peng; Shuming Zhang; Lin Wang; Mingli Hu; Jia-Cheng Liu; Yu Wei; Xue Xiao; Yan Li; Dongyu Li; Hui Wang; Bing-Rui Zhou; Linchang Dai; Zongjun Mou; Min Zou; Haonan Zhang; Zheng Zhou; Huidong Zhang; Yawen Bai; Jin-Qiu Zhou; Wei Li; Guohong Li*; Ping Zhu*.  Cell Research, 2024, In press.  Doi: 10.1038/s41422-024-01009-z.  
100. Copper exposure induces trophoblast cell cuproptosis by up-regulating lnc-HZ11.  Zhaodian Zheng#, Jing Fang#, Yanqiu Shen#, Chenyang Mi, Zhongyan Xu, Jingsong Zhao, Weina Chen, Ruining Han*, Qiong Lei*, and Huidong Zhang*.  Ecotoxicol. Environ. Saf., 2024, 281, 116641.  (0147-6513; https://doi.org/10.1016/j.ecoenv.2024.116641; Q1; IF: 7.284; 3 times; 中科院毒理学一区).  

99. BaP/BPDE exposure causes human trophoblast cell dysfunctions and induces miscarriage by up-regulating lnc-HZ06-regulated IL1B.  Jiarong Guo#, Jingsong Zhao#, Peng Tian#, Zhongyan Xu, Rong Wang, Weina Chen, Xiaoqing Wang, Shukun Wan, Yang Yang, and Huidong Zhang*.  J. Hazard. Mater., 2024, 466, 134741.  https://doi.org/10.1016/j.jhazmat.2024.134741  (0304-3894; Q1; IF: 14.224; cited by 0 times; 中科院环境科学一区).  

98. BaP/BPDE suppresses human trophoblast cell migration/invasion and induces miscarriage by up-regulating a novel lnc-HZ11 in extracellular vesicles: an intercellular study.  Chenyang Mi, Weina Chen, Ying Zhang, Yang Yang, Jingsong Zhao, Zhongyan Xu, Yi Sun, Qigang Fan, Wenxin Huang, Geng Guo*, and Huidong Zhang*.  Environ. Int., 2024, 188, 108750.  (0160-4120; Q1; IF: 11.8; cited by 2 times; 中科院环境科学一区).  

97. Environmental BaP/BPDE suppressed trophoblast cell invasion/migration and induced miscarriage by down-regulating lnc-HZ01/MEST/VIM axis.  Weina Chen#, Yuanlv Deng#, Yan Li#, Xinying Huang, Chenglong Ma, Wenxin Huang, Rong Wang, Zhaodian Zheng, Manli Wang and Huidong Zhang*.  Ecotoxicol. Environ. Saf., 2024, 278, 116409.  (0147-6513; https://doi.org/10.1016/j.ecoenv.2024.116409; Q1; IF: 7.284; 1 times; 中科院毒理学一区).  

96. Copper exposure causes placental cuproptosis and induced miscarriage in mice.  Jingsong Zhao#, Zhongyan Xu#*, Xiaoqing Wang, Shukun Wan, Weina Chen, Wenxin Huang, Manli Wang, Rong Wang, and Huidong Zhang*.  Environ. Pollut., 2024, 123847.  https://doi.org/10.1016/j.envpol.2024.123847. (0269-7491; Q1; IF: 8.9; cited by 3 times; 中科院环境二区) (Invited special issues).  

95. Lnc-HZ12 suppressed chaperone-mediated autophagy degradation of BBC3 to promote trophoblast cell apoptosis and induced miscarriage.  Jingsong Zhao#, Zhongyan Xu#, Jiayu Xie, Tingting Liang, Rong Wang, Weina Chen, Chenyang Mi, Peng Tian, Jiarong Guo, and Huidong Zhang*.  Autophagy, 2024, 2255-2274.  Doi: 10.1080/15548627.2024.2362122. (1554-8627; Q1; IF: 13.3; cited by 1 times; 中科院生物科学一区)  

94. Exposure to high dose of polystyrene nanoplastics causes trophoblast cell apoptosis and induces miscarriage.  Shukun Wan#, Xiaoqing Wang#, Weina Chen#, Manli Wang, Jingsong Zhao, Zhongyan Xu, Rong Wang, Chenyang Mi, Zhaodian Zheng, and Huidong Zhang*.  Part. Fibre Toxicol., 2024, 21, 13.  https://doi.org/10.1186/s12989-024-00574-w.  (1743-8977; Q1; IF: 10.0; cited by 11 times; 中科院医学一区) 

93. Hypoxia induces trophoblast cell ferroptosis and miscarriage by up-regulating lnc-HZ06/HIF1α-SUMO feedback loop.  Peng Tian#, Zhongyan Xu#, Jiarong Guo#, Jingsong Zhao, Manli Wang, Chenyang Mi, Wenxin Huang, Weina Chen, Yang Yang, Ying Zhang and Huidong Zhang*.  Redox Biol., 2024, 70, 103073.  https://doi.org/10.1016/j.redox.2024.103073.  (2213-2317; Q1; IF: 11.4; cited by 8 times; 中科院生物学一区) 

92. Polystyrene nanoplastics activates autophagy and suppresses trophoblast cell migration/invasion and migrasome formation to induce miscarriage.  Shukun Wan#, Xiaoqing Wang#, Weina Chen#, Zhongyan Xu, Jingsong Zhao, Manli Wang, Wenxin Huang, and Huidong Zhang*.  ACS Nano, 2024, 18, 3733-3751. https://doi.org/10.1021/acsnano.3c11734.  (1936-0851; Q1; IF: 17.1; cited by 13 times; 中科院材料科学一区) 

91. Defective homologous recombination repair by up-regulating lnc-HZ10/AhR loop in human trophoblast cells induced miscarriage.  Weina Chen, Chenyang Mi, Ying Zhang, Yang Yang, Wenxin Huang, Zhongyan Xu, Jingsong Zhao, Rong Wang, Manli Wang, Shukun Wan, Xiaoqing Wang and Huidong Zhang*.  Adv Sci, 2024, 2207435. DOI: 10.1002/advs.202207435.  (2198-3844; Q1; IF: 15.1; cited by 2 times; 中科院材料科学一区)  

90. Dichloroacetic acid and trichloroacetic acid in disinfection by-products of drinking water are endocrine-disrupting chemicals.  Weina Chen#, Xiaoqing Wang#, Shukun Wan#, Yang Yang, Ying Zhang, Zhongyan Xu, Jingsong Zhao, Chenyang Mi, and Huidong Zhang*.  J. Hazard. Mater., 2024, 466, 133035.  https://doi.org/10.1016/j.jhazmat.2023.133035. (0304-3894; Q1; IF: 14.224; cited by 4 times; 中科院环境科学一区)

[2023] 

89. BaP/BPDE suppressed endothelial cell angiogenesis to induce miscarriage by promoting MARCHF1/GPX4-mediated ferroptosis.  Ying Zhang#, Yang Yang#, Weina Chen, Chenyang Mi, Xiaole Xu, Yanqiu Shen, Zhaodian Zheng, Zhongyan Xu, Jingsong Zhao, Shukun Wan, Xiaoqing Wang, and Huidong Zhang*.  Environ. Int., 2023, 180, 108237.  https://doi.org/10.1016/j.envint.2023.108237.  (0160-4120; Q1; IF: 11.8; cited by 13 times; 中科院环境科学一区).  

88. BPDE exposure promotes trophoblast cell pyroptosis and induces miscarriage by up-regulating lnc-HZ14/ZBP1/NLRP3 axis.  Rong Wang#, Xiaole Xu#, Jingjing Yang#, Weina Chen, Jingsong Zhao, Manli Wang, Ying Zhang, Yang Yang, Wenxin Huang, and Huidong Zhang*. J. Hazard. Mater., 2023, 455, 131543.  (0304-3894; Q1; IF: 14.224; cited by 22 times; 中科院环境科学一区)  

87. 一种微小RNA在BPDE抑制滋养层细胞侵袭迁移中的作用和调控机制。杨阳, 张莹, 陈维娜, 米辰炀, 王晓庆, 万叔坤, 张慧东*。现代预防医学, 2023, 50, 1105。（1003-8507）

86. 长链非编码RNA NORAD抑制人脐静脉内皮细胞的血管生成。张莹, 杨阳, 陈维娜, 米辰炀, 万叔坤, 王晓庆, 张慧东*。现代预防医学, 2023, 50, 933。（1003-8507）

85. BPDE, the migration and invasion of human trophoblast cells and occurrence of miscarriage in humans: roles of a novel lncRNA-HZ09.  Mengyuan Dai#, Wenxin Huang#, Xinying Huang, Chenglong Ma, Rong Wang, Peng Tian, Weina Chen, Ying Zhang, Chenyang Mi, and Huidong Zhang*.  Environ. Health Persp., 2023, 131, 17009.  Doi: 10.1289/EHP10477. (selected as Science Selection) (0091-6765; Q1; IF: 11.720; cited by 24 times; 中科院环境科学和公共卫生一区).  

[2022] 

84. Structure and mutation analysis of the hexameric P4 from Pseudomonas aeruginosa phage phiYY.  Caiying Zhang, Yuelong Li, Abdus Samad, Peiyi Zheng, Zheng Ji, Feng Chen, Huidong Zhang, and , Tengchuan Jin*.  Int. J. Biol. Macromol. 2022, 194, 42-49. https://doi.org/10.1016/j.ijbiomac.2021.11.129. (0141-8130, Q1; IF: 8.2; 中科院化学一区).  

83. Regulatory roles of extracellular vesicles in adverse pregnancy outcomes exposed with environmental toxicants. Xiaoqing Wang#, Shukun Wan#, Chenyang Mi, Wenxin Huang, Rong Wang, and Huidong Zhang*.  Crit. Rev. Toxicol., 2022, 52, 867-880.  https://doi.org/10.1080/10408444.2023.2184325. (1040-8444, Q1; IF: 6.691; 0 times; 中科院医学二区).  

82. Regulatory roles of non-coding RNAs and m6A modification in trophoblast functions and the occurrence of its related adverse pregnancy outcomes.  Rong Wang#, Shukun Wan#, Xiaoqing Wang#, Wenxin Huang, Mengyuan Dai, Chenyang Mi, and Huidong Zhang*. Crit. Rev. Toxicol., 2022, 52, 681-713.  Doi.org/10.1080/10408444.2022.2144711.  (1040-8444, Q1; IF: 6.691; 7 times; 中科院医学二区).  

81. Lnc-HZ03 promotes TRBP-mediated splicing of pre-miR-hz03 to generate miR-hz03 in human trophoblast cells.  Jingsong Zhao#, Liqin Cheng#, Qicai Liu#, Tingting Liang, Jiayu Xie, Rong Wang, Weina Chen, Lin Ao and Huidong Zhang*.  Toxicol. Sci., 2022, 1-11. Doi: 10.1093/toxsci/kfac122.  (; 1745-7270; Q2; IF: 4.679; 4 times; 中科院医学二区).  

80. The effects of hypoxia on adverse pregnancy outcomes.  Chenglong Ma#, Zhaodian Zheng#, Yanqiu Shen#, Jing Fang#, Xinying Huang, Jiarong Guo, and Huidong Zhang*.  Genome Instability & Disease, 2022, 3, 295-310.  Doi.org/10.1007/s42764-022-00081-2. (2524-7662; 受邀论文).   

79. Environmental BPDE induced human trophoblast cell apoptosis by up-regulating lnc-HZ01/p53 positive feedback loop.  Xinying Huang#, Chenglong Ma#, Wenxin Huang, Mengyuan Dai, Jingjing Yang, Xiaole Xu, Yuanlv Deng, Yang Yang, Huidong Zhang*.  Ecotoxicol. Environ. Saf., 2022, 237, 113564 (0147-6513; doi.org/10.1016/j.ecoenv.2022.113564; Q1; IF: 7.284; 6 times; 中科院毒理学一区). 

78. Lnc-HZ05 regulates BPDE-inhibited human trophoblast cell proliferation and affects the occurrence of miscarriage by directly binding with miR-hz05.  Chenyang Mi, Weina Chen, Tingting Liang, Jiayu Xie, Zhongyan Xu, Wenxin Huang, Peng Tian, Shuming Zhang, Mengyuan Dai, and Huidong Zhang*.  Cell Biol. Toxicol. 2022, 38, 1137–1157. (doi: 10.1007/s10565-021-09687-w; Q1; IF: 6.819; 14 times; 中科院毒理学一区) 

77. Lnc-HZ08 regulates BPDE-induced trophoblast cell dysfunctions by promoting PI3K ubiquitin degradation and is associated with miscarriage.  Jiayu Xie#, Tingting Liang#, Jingsong Zhao, Zhongyan Xu, Peng Tian, Rong Wang, Chenyang Mi, Wenxin Huang, Weina Chen, Huidong Zhang*. Cell Biol. Toxicol. 2022, 38, 291-310.  (0742-2091; Doi.org/10.1007/s10565-021-09606-z; Q1; IF: 6.819; 30 times; 中科院毒理学一区)

[2021] 

76. BPDE induces human trophoblast cell ferroptosis by up-regulating iron metabolism and promoting GPX4 proteasomal degradation.  Peng Tian#, Zhongyan Xu#, Jiarong Guo, Jingsong Zhao, Rong Wang, Weina Chen, Yang Yang, Wenxin Huang, Chenyang Mi, and Huidong Zhang*.  Ecotoxicol. Environ. Saf., 2021, 228: 113028.  (0147-6513; https://doi.org/10.1016/j.ecoenv.2021.113028; Q1; IF: 7.284; 14 times; 中科院毒理学一区).  

75. Novel lncRNA-HZ04 promotes BPDE-induced human trophoblast cell apoptosis and abortion by up-regulating IP3R1/CaMKII/SGCB pathway by competitively binding with miR-hz04.  Wenxin Huang#, Mengyuan Dai#, Chenyang Mi, Tingting Liang, Taotao Qiu, Zhongyan Xu, Jiayu Xie, Weina Chen, Peng Tian, Shuming Zhang, and Huidong Zhang*.  FASEB J., 2021, 35: e21789. (1530-6860; doi:10.1096/fj.202100376RR; Biology Q1; IF: 6.103; 25 times; 中科院生物学二区)

74. Environmental pollutant benzo[a] pyrene upregulated long non-coding RNA HZ07 inhibits trophoblast cell migration by inactivating PI3K/AKT/MMP2 signaling pathway in recurrent pregnancy Loss.  Yang Ye#, Sushi Jiang#, Chenyang Mi, Tao Du, Tingting Liang, Huan Zhong, Jiayu Xie, Wenming Xu, Huidong Zhang*, and Xiaomiao Zhao*.  Reprod. Sci., 2021, 28(11):3085-3093.  (1933-7191; https://doi.org/10.1007/s43032-021-00630-2; Obstetrics & Gynecology Q3; IF: 3.103; 15 times; 中科院医学三区)

73. Environment and Female Reproductive Health, Advances in Experimental Medicine and Biology 1300, Editor, Springer Nature. 2021. (Invited Book; 0065-2598; https://doi.org/10.1007/978-981-33-4187-6; IF: 2.450) 

72. DNA Polymerase Gp90 Activities and Regulations on Strand Displacement DNA Synthesis Revealed at Single-molecule Level.  Shuming Zhang, Xue Xiao, Jingwei Kong, Ke Lu, Shuo-Xing Dou, Peng-Ye Wang, Lu Ma, Yuru Liu, Guohong Li, Wei Li* and Huidong Zhang*.  FASEB J. 2021, 35, e21607. (1530-6860; DOI: 10.1096/fj.202100033RR; Biology Q1; IF: 6.103; 0 times; 中科院生物学二区)  

71. Upregulated lnc-HZ02 and miR-hz02 inhibited migration and invasion by down-regulating FAK/SRC/PI3K/AKT pathway in BPDE-treated trophoblast cells.  Jiarong Guo#, Rui Li#, Zhongyan Xu#, Peng Tian, Rong Wang, Youzhu Li, Xia Qiu, Peng Zou, Mei He, Lin Ao*, Qicai Liu*, and Huidong Zhang*. J. Biochem. Mol. Toxicol. 2021, e22757. (1095-6670; DOI: https://doi.org/10.1002/jbt.22757; Toxicology Q3; IF: 3.568; 2 times; 中科院医学四区). 

70. Lnc-HZ01 with m6A RNA methylation inhibits human trophoblast cell proliferation and induces miscarriage by up-regulating BPDE-activated lnc-HZ01/MXD1 positive feedback loop.  Zhongyan Xu#, Peng Tian#, Jiarong Guo, Chenyang Mi, Tingting Liang, Jiayu Xie, Wenxin Huang, Mengyuan Dai, Weina Chen, and Huidong Zhang*.  Sci. Total Environ. 2021, 776:145950.  (0048-9697; DOI: https://doi.org/10.1016/j.scitotenv.2021.145950; Q1; IF: 10.753; Cited 48 times; 中科院环境科学一区)

69. LncRNA HOTAIR促进女性滋养层细胞迁移的机制。许仲妍, 郭佳蓉, 田鹏, 邓思思, 张慧东*。现代预防医学, 2021, 48, 1272-1276 (Cited by 2 times)。

68. MiR-184促进滋养层细胞凋亡而引起复发性流产的研究。梁婷婷, 赵靖嵩, 马成龙, 杨阳, 武雅婷, 谢嘉渝, 张慧东*。现代预防医学, 2021, 48, 1123-1127 (Cited by 2 times)。

67. LncRNA NEAT1抑制女性滋养层细胞增殖的研究。谢嘉渝, 马成龙, 赵靖嵩, 武雅婷, 杨阳, 梁婷婷, 张慧东*。现代预防医学, 2021, 48, 911-915 (Cited by 1 times)。

66. Novel lnc-HZ03 and miR-hz03 promote BPDE-induced human trophoblast cell apoptosis and induce miscarriage by upregulating p53/SAT1 pathway.  Tingting Liang#, Jiayu Xie#, Jingsong Zhao, Wenxin Huang, Zhongyan Xu, Peng Tian, Chenyang Mi, Mengyuan Dai, Shuming Zhang, and Huidong Zhang*. Cell Biol. Toxicol. 2021, 37(6):951-970.  (0742-2091; DOI：https://doi.org/10.1007/s10565-021-09583-3; Q1; IF: 6.819; 22 times; 中科院毒理学一区).  

[2020] 

65. Predicting the animal susceptibility and drugs to SARS-CoV-2 based on Spike glycoprotein combined with ACE2.  Min Shen, Chao Liu, Run Xu, Zijing Ruan, Shiying Zhao, Huidong Zhang, Wang Wen, Xinhe Huang, Li Yang, Yong Tang, Tai Yang, Xu Jia*.  Frontiers in Genetics, section Computational Genomics.  2020, In Press. (DOI.org/10.3389/fgene.2020.575012; 6 times）

64. Environmental Pollutant Benzo[a] pyrene Induces Recurrent Pregnancy Loss through Promoting Apoptosis and Suppressing Migration of Extravillous Trophoblast. Yang Ye, Sushi Jiang, Chao Zhang, Tao Du, Huan Zhong, Wenming Xu, Huidong Zhang* and Xiaomiao Zhao*. BioMed Res. Int. 2020, 8983494. DOI: doi.org/10.1155/2020/8983494. (2314-6133, IF: 3.767;  Biochemistry & Molecular Biology Q2; Cited 22 times; 生物三区)

63. Mechanisms of mutagenesis induced by DNA lesions: multiple factors affect mutations in translesion DNA synthesis. Huidong Zhang*. Crit. Rev. Biochem. Mol. Biol., 55: 219-251, 2020. DOI: 10.1080/10409238.2020.1768205.(Invited; 1040-9238, IF: 10.006; Biochemistry & Molecular Biology Q2; 6 times; 中科院生物学二区)

62. Dynamic structural insights into the molecular mechanism of DNA unwinding by the bacteriophage T7 helicase. Jianbing Ma#, Ze Chen#, Chunhua Xu#, Xingyuan Huang, Qi Jia,Zhenyu Zou, Chenyang Mi,Dongfei Ma, Ying Lu*, Huidong Zhang*, and Ming Li*. Nucleic Acids Res., 48: 3156-3164, 2020. DOI: 10.1093/nar/gkaa057.(0305-1048, IF: 19.160; Cited 12 times; Biology Q1; 中科院生物学二区)

61. Strand-displacement DNA synthesis by DNA polymerase gp90 exo- of Pseudomonas aeruginosa phage 1. Chenyang Mi#, Shuming Zhang#, Wenxin Huang, Mengyuan Dai, Zili Chai, Wang Yang, Shanshan Deng, Lin Ao*, and Huidong Zhang*.Biochimie,170: 73-87, 2020. DOI: 10.1016/j.biochi.2019.12.013. (0300-9084, IF: 4.372; Cited 2 times; Biochemistry & Molecular Biology Q3; 中科院生物学三区)

60. Epigenetically modified N6-methyladesine inhibits DNA replication by human DNA Polymerase iota. Shuming Zhang, Bianbian Li, Ke Du, Tingting Liang, Mengyuan Dai, Wenxin Huang, Huizhi Zhang, Yihui Ling, and Huidong Zhang*. Biochimie, 168: 134-143, 2020. DOI: 10.1016/j.biochi.2019.10.018 (0300-9084, IF: 4.372; Cited 8 times; Biochemistry & Molecular Biology Q3; 中科院生物学三区)

[2019] 

59. Epigenetic DNA Modification N6-methyladenine inhibits DNA replication bySulfolobus solfataricus Y-family DNA Polymerase Dpo4. Ke Du, Shuming Zhang, Weina Chen, Mengyuan Dai, Zhongyan Xu, Tingting Liang, Wenxin Huang, Yihui Ling, and Huidong Zhang*. Arch. Biochem. Biophys., 675: 108-120, 2019. DOI: 10.1016/j.abb.2019.108120. (0003-9861, IF: 4.270; Cited 6 times; Biochemistry & Molecular Biology Q3; 生物三区)

58. Ribonucleoside Triphosphates Promote T7 DNA Replication and the Lysis of T7-Infected Escherichia coli. Zhenyu Zou, Wendi Xu, Chenyang Mi, Ying Xu, Ke Du, Bianbian Li, Yang Ye, Yihui Ling, and Huidong Zhang*. Biochimie, 167: 25-33, 2019. DOI: 10.1016/j.biochi.2019.09.002. (0300-9084, IF: 4.372; Cited 1 times; Biochemistry & Molecular Biology Q3)

57. Protein Interactions in T7 DNA Replisome Inhibit the Bypass of Abasic Site by DNA polymerase. Zhenyu Zou, Tingting Liang, Zhongyan Xu, Jiayu Xie, Shuming Zhang, Weina Chen, Siqi Wan, Yihui Ling, and Huidong Zhang*. Mutagenesis, 34: 355-361, 2019. DOI:10.1093/mutage/gez013.(IF: 3.492; Cited 1 times; Biology Q3; 医学三区). 

56. Epigenetic DNA modification N6-methylAdesine inhibits DNA replication by DNA Polymerase ofPseudomonas aeruginosa Phage PaP1. Bianbian Li, Ke Du, Shiling Gu, Jiayu Xie, Tingting Liang,Zhongyan Xu, Hui Gao,Yihui Ling, Shuguang Lu, Zhen Sun*, and Huidong Zhang*. Chem. Res. Toxicol., 32: 840-849, 2019. DOI: 10.1021/acs.chemrestox.8b00348. (0893-228X, IF: 4.052; Cited 8 times; Toxicology Q2; 医学三区)

55. Epigenetically modified N6-methylAdesine inhibits DNA replication by human DNA Polymerase eta. Ke Du#, Xiangqian Zhang#, Zhenyu Zou, Bianbian Li, Shiling Gu, Shuming Zhang, Xiaoyi Qu, Yihui Ling, and Huidong Zhang*. DNA Repair, 2019, 78, 81-90. DOI: 10.1016/j.dnarep.2019.03.015. (1568-7864, IF: 4.821; Cited 14 times; Toxicology Q2; 医学三区)

54. lncRNA在女性生殖系统恶性肿瘤中的功能和作用机制。梁婷婷, 米辰炀, 谢嘉渝, 许仲妍, 杨舒, 张慧东*。环境与职业医学, 2019, 36, 243-249.（应邀专刊：环境和女性生殖健康; cited by 5 times）。

53. RNA的m6A修饰在女性生殖健康中的作用和机制。许仲妍#, 谢嘉渝#, 田震, 梁婷婷, 陈维娜, 李雪莹, 王瑜阳, 张慧东*。环境与职业医学, 2019, 36, 226-231.（应邀专刊：环境和女性生殖健康; cited by 2 times）。

52. 多环芳烃暴露致女性生殖毒性及其分子机制。米辰炀, 许仲妍, 谢嘉渝, 陈维娜, 李雪莹, 方鑫*, 张慧东*。环境与职业医学, 2019, 36, 43-49.（应邀专刊：环境和女性生殖健康; cited by 11 times）。

51. "环境与女性生殖健康"专栏之序。张慧东。环境与职业医学, 2019, 36, 33-34.（应邀专刊：环境和女性生殖健康，专刊组稿负责人）。

[2018] 

50. Egg yolk immunoglobulins supplementation prevents rat liver from aflatoxin B1-induced oxidative damage and genotoxicity. Taotao Qiu, Xing Shen, Xiangmei Li, Yunyun Gong, Zhongmin Zou, Chunhong Liu, Feng Ye, Chenyang Mi, Zhenlin Xu, Yuanming Sun, Jie Lin, Huidong Zhang*, and Hongtao Lei*. J. Agric. Food Chem., 66: 13260-13267, 2018. DOI: 10.1021/acs.jafc.8b04659. (0021-8561, IF: 6.048; Cited 7 times; Agriculture Q1). 

49. Benzo[a] pyrene-7,8-diol-9,10-epoxide suppresses the migration and invasion of human extravillous trophoblast Swan71 cells due to the inhibited filopodia formation and down-regulated PI3K/AKT/CDC42/PAK1 pathway mediated by the increased miR-194-3p. Zhen Tian#, Rong Wang#, Xi Zhang, Bin Deng, Chenyang Mi, Tingting Liang, Yihui Ling, Hongli Li, and Huidong Zhang*. Toxicol. Sci., 166: 25-38, 2018. DOI: 10.1093/toxsci/kfy182. (1096-6080, IF: 4.679; Cited 23 times; Medicine Q2)

48. Protein Interactions in T7 DNA Replisome Facilitate DNA Damage Bypass. Zhenyu Zou#, Ze Chen#, Qizhen Xue, Ying Xu, Jingyuan Xiong, Ping Yang, Shuai Le*, and Huidong Zhang*. ChemBioChem, 19, 1740-1749, 2018. DOI: 10.1002/cbic.201800203. (1439-4227, IF: 3.461; Cited 4 times; BiologyQ3) 

47. Consecutive Ribonucleoside Monophosphates on Template Inhibit DNA Replication by T7 DNA Polymerase or by T7 Polymerase and Helicase Complex. Zhenyu Zou, Ze Chen, Yin Cai, Huang Yang, Ke Du, Bianbian Li, Yiguo Jiang, and Huidong Zhang*. Biochimie, 151: 128-138, 2018. https://doi.org/10.1016/j.biochi.2018.05.022. (0300-9084, IF: 4.372; Cited 5 times; Biochemistry & Molecular Biology Q3)

46. T7 helicase unwinding and stand switching investigated via single-molecular technology. Ze Chen, Jianbing Ma, Xingyuan Huang, Qi Jia, Chunhua Xu, Huidong Zhang* and Ying Lu*.  Acta Phys. Sin. 2018, 67: 118201.  (1000-3290; IF: 0.819: Q4; 2 times).  

45. Pseudomonas aeruginosa MutL promotes large chromosomal deletions through non-homologous end joining to prevent bacteriophage predation. Mengyu Shen#, Huidong Zhang#, Shen Wei, Zhenyu Zou, Shuguang Lu, Gang Li,Xuesong He, Melissa Agnello, Wenyuan Shi*, Fuquan Hu*, and Shuai Le*. Nucleic Acids Res., 46: 4505-4514, 2018. DOI: 10.1093/nar/gky160. (0305-1048, IF: 19.160; Cited 39 times; Biology Q1) 

44. General misincorporation frequency: re-evaluation of the fidelity of DNA polymerases. Jie Yang, Bianbian Li, Xiaoying Liu, Hong Tang, Xiyao Zhuang, Mingqi Yang, Ying Xu, Huidong Zhang*, and Chun Yang*. Biochem. Biophys. Res. Commun., 496: 1076-1081, 2018. DOI: https://doi.org/10.1016/j.bbrc.2018.01.135. (0006-291X, IF: 3.498; Cited 6 times; Biology Q3) 

43. IgY reduces AFB1-induced cytotoxicity, cellular dysfunction, and genotoxicity in human L-02 hepatocytes and Swan 71 trophoblasts. Taotao Qiu, Xing Shen, Zhen Tian, Riming Huang, Xiangmei Li, Juan Wang, Rong Wang, Yuanming Sun, Yiguo Jiang, Hongtao Lei* and Huidong Zhang*. J. Agric. Food Chem., 66: 1543-1550, 2018. DOI: 10.1021/acs.jafc.7b05385. (0021-8561, IF: 6.048; Cited 11 times; Agriculture Q1)

42. Single-stranded DNA hybridization facilitated by T7 single-stranded DNA binding protein (gp2.5) rapidly initiates from the strandterminus or internally followed by a slow zippering step. Zhenyu Zou#, Siying Wu#, Jingyuan Xiong, Huangyuan Li, Yiguo Jiang, and Huidong Zhang*. Biochimie, 147: 1-12, 2018. DOI: 10.1016/j.biochi.2017.12.012. (0300-9084, IF: 4.372; Cited 7 times; Biochemistry & Molecular Biology Q3) 

41. Bypass of an abasic site via the A-rule by DNA polymerase of Pseudomonas aeruginosa phage PaP1. Xiaoying Liu, Xiaoli Zou, Huangyuan Li, Zhenyu Zou, Jie Yang, Chenlun Wang,Shunhua Wu*, and Huidong Zhang*. Chem. Res. Toxicol.,31: 58-65, 2018. DOI: 10.1021/acs.chemrestox.7b00287. (0893-228X, IF: 4.052; Cited 11 times; Toxicology Q2; 医学三区)

40. Benzo(a)pyren-7,8-dihydrodiol-9,10-epoxide induces human trophoblast Swan 71 cells dysfunctions due to cell apoptosis through disorder of mitochondrial fission/fusion. Weiping Wang, Rong Wang, Qiao Zhang, Gil Mor, and Huidong Zhang*. Environ. Pollut., 233: 820-832, 2018. DOI: 10.1016/j.envpol.2017.11.022. (0269-7491, IF: 10.366; Cited 45 times; Environmental science Q2)

[2017] 

39. ALX4, an epigenetically down regulated tumor suppressor, inhibits breast cancer progression by interfering Wnt/β-catenin pathway. Juntang Yang#, Fei Han#, Wenbin Liu, Hongqiang Chen, Xianglin Hao, Xiao jiang, Li Yin, Yongsheng Huang, Jia Cao, Huidong Zhang, and Jinyi Liu*. J. Exp. Clin. Cancer Res., 36: 170, 2017. DOI: 10.1186/s13046-017-0643-9. (1756-9966; IF: 5.646; Cited 17 times; Oncology Q2)

38. LHX6, an independent prognostic factor, inhibits lung adenocarcinoma progression through transcriptional silencing of β-catenin. Juntang Yang, Fei Han, Wenbin Liu, Mingqian Zhang, Yongsheng Huang, Xianglin Hao, Xiao Jiang, Li Yin, Hongqiang Chen, Jia Cao, Huidong Zhang* and Jinyi Liu*. J. Cancer, 8: 2561-2574, 2017. DOI: 10.7150/jca.19972. (1837-9664, IF: 3.249; Cited 10 times; Oncology Q3)

37. Error-prone bypass of O6-methylguanine by DNA polymerase of Pseudomonas aeruginosa phage PaP1. Shiling Gu#, Jingyuan Xiong#, Ying Shi, Jia You,Zhenyu Zou, Xiaoying Liu, and Huidong Zhang*. DNA Repair, 57: 35-44, 2017. DOI: http://dx.doi.org/10.1016/j.dnarep.2017.06.021. (1568-7864, IF: 4.821; Cited 15 times; Toxicology Q2;医学三区)

36. Benzo[a] pyrene-7,8-diol-9,10-epoxide suppresses the migration and invasion of human extravillous trophoblast HTR-8/SVneo cells by down-regulating MMP2 through inhibition of FAK/SRC/PI3K/AKT/eNOS pathway. Rong Wang, Weiping Wang, Lin Ao, Zi Wang, Xianglin Hao, and Huidong Zhang*. Toxicology, 386: 72-83, 2017. DOI: http://dx.doi.org/10.1016/j.tox.2017.05.008. (0300-483X, IF: 4.821; Cited 45 times; Toxicology Q2)

35. Error-free bypass of 7,8-dihydro-8-oxo-2’-deoxyguanosine by DNA polymerase of Pseudomonas aeruginosa phage PaP1. Shiling Gu, Qizhen Xue, Qin Liu, Mei Xiong, Wanneng Wang*, and Huidong Zhang*. Genes, 8: 18, 2017. DOI: 10.3390/genes8010018. (Invited; 2073-4425; IF: 3.331; Cited 14 times; Genetics & Heredity Q2)

34. Low-concentration serum promotes the adhesion andspreading of mouse fibroblast L929 cell onhydrophobic glass surface. Weiping Wang#, Rong Wang#,Peng Qin#, Huan Yang, Changguo Ma, Fan Zhang, Qiao Zhang*, Yuehua Cui*, and HuidongZhang*. J. Biomater. Tissue Eng., 7: 333-342, 2017. DOI: https://doi.org/10.1166/jbt.2017.1572. (2157-9083; IF: 2.066; Cited 3 times; Cell & Tissue Engineering Q4)

[2016] 

33. Pseudomonas aeruginosa phage PaP1 DNA polymerase is an A-family high processive DNA polymerase with ssDNA and dsDNA 3 to 5 exonuclease activity. Binyan Liu, Shiling Gu, Nengsong Liang, Mei Xiong, Qizhen Xue, Shuguang Lu, Fuquan Hu, and Huidong Zhang*. Virus Genes, 52:538-551, 2016. DOI:10.1007/s11262-016-1329-7. (IF: 1.845; Cited 10 times; virus Q4) 

32. Kinetic analysis of bypass of O6-methylguanine by the catalytic core of yeast DNA polymerase eta. Binyan Liu#, Qizhen Xue#, Shiling Gu,Weiping Wang, Jie Chen, Yingqing Li, Chunxue Wang, and Huidong Zhang*. Arch. Biochem. Biophys., 596: 99-107, 2016. DOI:10.1016/j.abb.2016.03.009. (0003-9861, IF: 4.270; Cited 16 times; Biochemistry & Molecular Biology Q3; 生物三区)

31. Mechanisms of mutagenesis: DNA replication in the presence of DNA damage.Binyan Liu, Qizhen Xue, Yong Tang, Jia Cao, F. Peter Guengerich, and Huidong Zhang*. Mutat. Res. Rev.,768: 53-67, 2016. DOI:10.1016/j.mrrev.2016.03.006. (Invited; 1383-5742, IF: 7.403; Cited 37 times; Toxicology Q1).  

30. Kinetic analysis of bypass of 7,8-dihydro-8-oxo-2´-deoxyguanosine by the catalytic core of yeast DNA polymerase eta. Qizhen Xue#, Mengyu Zhong#, Binyan Liu, Yong Tang, Zeliang Wei, F. Peter Guengerich, and Huidong Zhang*. Biochimie, 121: 161-169, 2016. DOI:10.1016/j.biochi.2015.12.009. (0300-9084, IF: 4.372; Cited 15 times; Biochemistry & Molecular Biology Q3)

29. Binding affinities among helicase, DNA polymerase and replication intermediate DNA in the T7 DNA replisome. Huidong Zhang*,Yong Tang, Seung-Joo Lee, Zeliang Wei, Jia Cao, and Charles C. Richardson*. J. Biol. Chem., 291: 1472-1480, 2016. DOI:10.1074/jbc.M115.698233. (0021-9258, IF: 5.486; Cited 19 times; Biology Q2)

[2015] 

28. DNA Replication-Damage from Environmental Carcinogens. Huidong Zhang*. Invited Briefs, Springer Briefs in Biochemistry and Molecular Biolgy, 2015, 1-51. (Invited)

27. Kinetic analysis of bypass of abasic site by the catalytic core of yeast DNA polymerase eta. Juntang Yang#, Rong Wang#, Binyan Liu, Qizhen Xue, Mengyu Zhong, Hao Zeng, and Huidong Zhang*. Mutat. Res.-Fund. Mol. M., 779: 134-143, 2015. DOI: 10.1016/j.mrfmmm.2015.07.001. (0027-5107, IF: 3.680; Cited 15 times; Toxicology Q2)

[2014] 

26. Epigenetic regulation of SOX30 is associated with testis development in mice. Fei Han, Yan Dong, Wenbin Liu, Xuexiang Ma, Ronghui Shi, Hongqiang Chen, Zhihong Cui, Lin Ao, Huidong Zhang, Jia Cao, and Jinyi Liu*. PLoS One, 9(5): e97203, 2014. DOI:10.1371/Journal.pone.0097203. (1932-6203, IF: 3.234; Cited 35 times; Multidisciplinary Sciences Q2)

[2012] 

25. Heterohexamer of 56- and 63-kDa gene 4 helicase-primase of bacteriophage T7 in DNA replication. Huidong Zhang#, Seung-Joo Lee, Arkadiusz W. Kulczyk, Bin Zhu, and Charles C. Richardson*. J. Biol. Chem.,287: 34273-34287, 2012. DOI:10.1074/jbc.M112.401158. (0021-9258, IF: 5.486; Cited 11 times; Biology Q2)

24. The roles of tryptophans in primer synthesis by the DNA primase of bacteriophage T7. Huidong Zhang#, Seung-Joo Lee#, and Charles C. Richardson*. J. Biol. Chem.,287: 23644-23656, 2012.DOI:10.1074/jbc.M112.366096. (0021-9258, IF: 5.486; Cited 8 times; Biology Q2)

[2011] 

23. Essential protein interactionswithin the replisome regulate DNA replication. Huidong Zhang, Seung-Joo Lee, and Charles C. Richardson*. Cell Cycle, 10:3413-3414, 2011. DOI:10.4161/cc.10.20.17523. (Invited feature article;1538-4101,  IF: 5.173; Cited 6 times; Cell Biology Q2)

22. Helicase-DNA polymerase interaction is critical to initiate leading-strand DNA synthesis. Huidong Zhang#,Seung-Joo Lee#, Bin Zhu, Ngoc Q. Tran, Stanley Tabor, and Charles C. Richardson*. Proc. Natl. Acad. Sci. USA, 108:9372-9377, 2011. DOI:10.1073/pnas.1106678108. (0027-8424, IF: 13.450; Cited 54 times; Multidisciplinary Sciences Q1)

[2010] 

21. Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases. Huidong Zhang, Urban Bren, Ivan D. Kozekov, Carmelo J. Rizzo, Donald F. Stec, and F. Peter Guengerich*. 238th American-Chemical-Society National Meeting. Washington, DC.AUG 16-20, 2009. Chem. Res. Toxicol., 23: 275-275, 2010. (0893-228X, IF: 4.052; Chemistry, Medicinal Q2; 0 times; 医学三区)

20. Effect of N2-guanyl modifications on early steps in catalysis of polymerization by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W. Huidong Zhang and F. Peter Guengerich*. J. Mol. Biol.,395:1007-1018, 2010.DOI:10.1016/j.jmb.2009.11.071. (0022-2836, IF: 4.008; Cited 29 times; Biochemistry & Molecular Biology Q2)

[2009] 

19. Frameshift deletion by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W is selective for purines and involves normal conformational change followed by slow phosphodiester bond formation. Huidong Zhang, Jeff W. Beckman, and F. Peter Guengerich*. J. Biol. Chem.,284:35144-35153, 2009. DOI: 10.1074/jbc.M109.067397. (0021-9258, IF: 5.328; Cited 13 times; Biology Q2)

18. Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases. Huidong Zhang, Urban Bren, Ivan D. Kozekov,Carmelo J. Rizzo, Donald F. Stec, and F. Peter Guengerich*. J. Mol. Biol., 392:251-269, 2009. DOI: 10.1016/j.jmb.2009.07.019. (0022-2836, IF: 4.008; Cited 26 times; Biochemistry & Molecular Biology Q1)

17. Structure-function relationships in miscoding by Sulfolobus solfataricus DNA polymerase Dpo4. Guanine N2, N2-dimethyl substitution produces inactive and miscoding polymerase complexes. Huidong Zhang#, Robert L. Eoff#, Ivan D. Kozekov, Carmelo J. Rizzo,Martin Egli, and F. Peter Guengerich*. J. Biol. Chem., 284:17687-17699, 2009.DOI: 10.1074/jbc.M109014274. (0021-9258, IF: 5.328; Cited 33 times; Biology Q2)

16. Versatility of Y-family sulfolobus solfataricus DNA polymerase Dpo4 in translesion synthesis past bulky N2-alkyl guanine adducts. Huidong Zhang#,Robert L. Eoff#, Ivan D. Kozekov, Carmelo J. Rizzo,Martin Egli, and F. Peter Guengerich*. J. Biol. Chem.,284:3563-3576, 2009. DOI: 10.1074/jbc.M807778200. (Cover paper; 0021-9258,  IF: 5.328; Cited 53 times; Biology Q2)

[2008] 

15. Effect of N2-alkylguanine adducts on replication by Y-class Sulfolobus solfataricus DNA Polymerase Dpo4. Huidong Zhang, Robert L. Eoff, Karen C. Angel, and F. Peter Guengerich*. 236th National Meeting of the American-Chemical-Society. Philadelphia, PA. AUG 17-21, 2008. Chem. Res. Toxicol., 21: 2443, 2008. (0893-228X, IF: 4.052; Cited 1 times; Toxicology Q2; 医学三区)

14. Template enhanced activity of lipase accommodated in siliceous mesocellular foams. Yanmei Zhang, Lifang Zhao, Jun Li, Huidong Zhang, Liangyu Zheng, Shugui Cao*, and Can Li*. Biochem. Biophys. Res. Commun.,372:650-655, 2008. DOI: 10.1016/j.bbrc.2008.05.089. (0006-291X, IF: 3.498; Cited 16 times; Biochemistry & Molecular Biology Q3) 

13. Asymmetric hydroformylation of olefins catalyzed by rhodium nanoparticles chirally stabilized with (R)-BINAP ligand. Difei Han, Xiaohong Li, Huidong Zhang, Zhimin Liu, Gengshen Hu, and Can Li*. J. Mol. Catal. A: Chem., 283:15-22, 2008. DOI: 10.1016/j.molcata.2007.12.008. (1381-1169, IF: 3.160; Cited 49 times; Chemistry, Physical Q3)

12. An efficient resolution of racemic secondary alcohols on magnetically separable biocatalyst. Yanmei Zhang, Jun Li, Difei Han, Huidong Zhang, Peng Liu, and Can Li*. Biochem. Biophys. Res. Commun., 365: 609-613, 2008. DOI: 10.1016/j.bbrc.2007.10.205.(0006-291X, IF: 3.498; Cited 45 times; Biochemistry & Molecular BiologyQ3)

[2007] 

11. Kinetic study of the catalytic reforming of CH4 with CO2 to syngas over Ni/ alpha-Al2O3 catalyst: The effect of temperature on the reforming mechanism. Yuehua Cui, Huidong Zhang, Hengyong Xu*, and Wenzhao Li. Appl. Catal. A: Gen., 318:79-88, 2007. DOI: 10.1016/j.apcata.2006.10.044. (0926-860X, IF: 3.942; Cited 90 times; Environmental Sciences Q2)

10. The CO2 reforming of CH4 over Ni/La2O3/alpha-Al2O3 catalysts: The effect of La2O3 contents on the kinetic performance. Yuehua Cui, Huidong Zhang, Hengyong Xu*, and Wenzhao Li. Appl. Catal. A: Gen., 331: 60-69, 2007. DOI: 10.1016/j.apcata.2007.06.039. (0926-860X, IF: 3.942; Cited 72 times; Environmental Sciences Q2)

9. Kinetic depressing the deposition of carbon species on Ni-based catalysts: La2O3 adjusts the reaction rates of CO2 higher than CH4 by tuning the Ea and pre-exponential factor. Yuehua Cui, Huidong Zhang, Hengyong Xu*, Qingjie Ge, Yuzhong Wang, Shoufu Hou, and Wenzhao Li. Stud. Surf. Sci. Catal., 167: 281-286, 2007.  DOI: 10.1016/S0167-2991(07)80145-5 (Cited 2 times)

8. Chiral synthesis on catalysts in nanopores. Can Li*, Huidong Zhang, Dongmei Jiang, and Qihua Yang. Chem. Commun., 6: 547-558, 2007. DOI: 10.1039/b609862b. (Invited feature article; 1359-7345,  IF: 6.169; Cited 197 times; Chemistry Q1)

[2006] 

7. Heterogeneous asymmetric hydroformylation of olefins on chirally modified Rh/SiO2 catalysts. Difei Han, Xiaohong Li, Huidong Zhang, Zhimin Liu, Jun Li, and Can Li*. J. Catal., 243: 318-328, 2006. DOI: 10.1016/j.jcat.2006.08.003. (0021-9517, IF: 6.201; Cited 66 times; Chemistry, Physical Q1)

6. Asymmetric epoxidation of 6-cyano-2,2-dimethylchromene on Mn(salen) catalyst immobilized in mesoporous materials. Huidong Zhangand Can Li*. Tetrahedron, 62: 6640-6649, 2006. DOI:10.1016/j.tet.2006.01.117. (Invited paper; 0040-4020,  IF: 3.060; Cited 83 times; Chemistry, Organic Q3)

5. Enantioselective epoxidation of unfunctional olefins catalyzed by the Mn(salen) catalysts immobilized in the nanopores of mesoporous materials. Huidong Zhang,Yanmei Zhang, and Can Li*. J. Catal., 238: 369-381, 2006. DOI: 10.1016/j.jcat.2005.12.023.(0021-9517, IF: 6.201; Cited 131 times; Chemistry, Physical Q1)

[2005] 

4. Asymmetric epoxidation of unfunctional olefins catalyzed by Mn(salen) axially immobilized onto insoluble polymers. Huidong Zhang,Yanmei Zhang, and Can Li*. Tetrahedron: Asymmetry, 16: 2417-2423, 2005. DOI: 10.1016/j.tetasy.2005.05.034. (IF: 2.652; Cited 44 times; Chemistry, Organic Q3)

3. Heterogeneous enantioselective epoxidation catalyzed by Mn(salen) complexes grafted onto mesoporous materials by phenoxyl group. Huidong Zhang, Song Xiang, Jianliang Xiao, and Can Li*. J. Mol. Catal. A: Chem., 238: 175-184, 2005. DOI: 10.1016/j.molcata.2005.05.024. (1381-1169, IF: 3.160; Cited 85 times; Chemistry, Physical Q3)

2. Enantioselective epoxidation of unfunctional olefins catalyzed by Mn(salen) complexes immobilized in porous materials via phenyl sulfonic group. Huidong Zhang,Song Xiang, and Can Li*. Chem. Commun., 1209-1211, 2005. DOI: 10.1039/b417041e. (1359-7345, IF: 6.169; Cited 145 times; Chemistry Q1)

1. The surface sites of sulfated zirconia studied in situ by laser-induced fluorescence spectroscopy. Jun Chen, Zhaochi Feng, Jianying Shi, Pinliang Ying, Huidong Zhang, and Can Li*. Chem. Phys. Lett., 401: 104-108, 2005. DOI: 10.1016/ j.cplett.2004.11.039. (0009-2614, IF: 1.897; Cited 5 times; Physics, Atomic, Molecular & Chemical Q3)

 

教授、主任医师、博士生导师。广东省人民医院心血管内科主任医师。

医疗专长：从事心血管内科专业30余年，在各种心血管常见病、多发病的治疗方面具有精湛的技术，并对心血管病各种急、危、重症的治疗有较高的造诣。主要特长是复杂高危冠心病内科诊断和介入治疗，尤其是慢性闭塞病变的介入治疗，是亚洲著名的心血管病专家。

学会任职：广东省冠心病防治研究重点实验室学术委员会主任委员、美国心脏病学院会员、中国医师协会心血管内科医师分会副会长等。

学术成就：发表有关心血管专业的临床论著50多篇，获国家级、省部级和卫生厅科技成果进步奖共7项，副主编著作1本，曾作为主要研究者参与OASIS-5、TIMI-25、MILESTONE-1、CCS-2、ORIGIN、SINO-SIRIUS、CCSR.TAXUS、MICE等多个国际多中心临床试验。

出诊信息：每月一次，以实际排班为准。

教授，主任医师，硕士生导师。曾任中山大学附属第一医院肾内科主任。中山大学教学督导员。

医疗专长：擅长肾脏内科疾病诊治，如肾小球肾炎、泌尿系感染、急慢性肾功能不全等的诊断和治疗及血液净化疗法、肾脏移植方面有丰富的临床经验。

学术成就：获广东省科委和中山医科大学等重点项目基金资助5项；在国际和全国性杂志公开发表的第1作者学术论著和文章15篇；参与专著或全国性教材的撰写7部；获卫生部和省卫生厅以及中山医科大学科技成果奖共3项。
 

副主任医师，硕士生导师，广州医科大学附属第三医院器官移植科副主任。

医疗专长：从事肝移植、肾移植临床、科研以及公民逝世后人体器官捐献工作16年，在公民逝世后人体器官捐献、器官获取，肝脏、肾脏移植及术后管理、并发症处理具有丰富的经验。

学会任职：中国人体健康科学促进会人体器官和组织捐献专业委员会常委、广东省医学会器官移植学分会常委、广东省泌尿生殖协会肾脏移植分会常委。

学术成就：主持或参与省、市与学校等多级课题8项，发表SCI和中文核心期刊论文25篇，参编参译专著4部，其中副主编3部。

教授、主任医师、博士生导师、曾任中山大学肿瘤防治中心头颈外科科主任、甲状腺癌资深首席专家、澳大利亚皇家阿德雷德医院头颈科访问学者。

主要研究方向:甲状腺癌、喉癌微创治疗。

学会任职：中国医师协会外科医师分会甲状腺外科工作组顾问；中国医师协会外科医师分会甲状腺外科医师委员会副主任委员；中国研究型医院学会甲状腺疾病专业委员会副主任委员等。

学术成就: 近年以第一作者或通讯作者身份发表文章19篇，以第一负责人承担科研项目6项；作为编委参与国内各大甲状腺肿瘤相关指南的撰写，以副主编审查撰写《临床肿瘤学》、 《实用头颈肿瘤学》、 《肿瘤学》等教材。