药学部
施雷雷
职称:副研究员
科室:药学部
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简介

施雷雷,中山大学(百人计划,副研究员(一级)),博士生导师。2018年12月博士毕业于上海交通大学化学化工学院,师从朱新远教授(长江学者、国家杰青,上海交通大学副校长)。2019年2月至2021年4月期间,在新加坡国立大学从事博士后研究,合作导师刘斌教授(新加坡国家科学院院士,新加坡国家工程院院士,新加坡国立大学副校长)。2021年7月入选中山大学百人计划,加盟中山大学第八医院(深圳)筹建生物活性光敏剂研究团队。

近年来以第一作者,共同第一作者在国际学术期刊上发表论文20余篇,其中中科院一区论文13篇,包括Angew. Chem., ACS Nano. Advanced Functional Materials, Small, Biomaterials等领域内权威杂志,发表于Angew. Chem的论文入选ESI热点论文,相关成果得到了国际学术同行的认可,并被纳米人、X-MOL 以及 Wiley Chemistry等作为研究亮点报道。以第一发明人申请发明专利一项,2021年8月获得国家自然科学基金青年项目资助。

研究方向:聚集诱导发光材料的生物医学应用,抗肿瘤创新药物设计,纳米药物递送

代表性论文:

1.    Leilei Shi, Wenbo Wu, Yukun Duan, Li Xu, Sha Li, Xihui Gao*, and Bin Liu*. “Carrier-Free Hybrid DNA Nanoparticles for Light-induced Self-Delivery of Functional Nucleic Acid Enzymes” ACS Nano, 15 (2021), 1841-1849. (IF: 15.881, 1区)

2.    Wenbo Wu#, Leilei Shi# (Co-first author), Yukun Duan, Shidang Xu, Lingyue Shen, Ting Zhu, Lidan Hou, Xiangjun Meng, Bin Liu*. “Nanobody Modified High-Performance AIE Photosensitizer Nanoparticles for Precise Photodynamic Oral Cancer Therapy of Patient-Derived Tumor Xenograft” Biomaterials, (2021) 274, 120870. (IF: 12.479, 1区)

3.    Yuanbo Wang#, Leilei Shi# (Co-first author), Wenbo Wu#, Guobin Qi, Xinyuan Zhu, Bin Liu*. “Tumor-Activated Photosensitization and Size Transformation of Nanodrugs” Advanced Functional Materials, 2021, 2010241. (IF: 18.808, 1区)

4.    Leilei Shi, Wenbo Wu, Yukun Duan, Li Xu, Yingying Xu, Lidan Hou, Xiangjun Meng, Xinyuan Zhu, and Bin Liu*. “Light Induced Self-Escape of Spherical Nucleic Acid from Endo/Lysosome for Efficient Non-Cationic Gene Delivery” Angew. Chem. Int. Ed., 59 (2020), 19168-19174. (IF: 15.336, 1区)

5.    Leilei Shi, Fang Hu, Yukun Duan, Wenbo Wu, Jinqiao Dong, Xiangjun Meng, Xinyuan Zhu, Bin Liu*. “Hybrid Nanospheres to Overcome Hypoxia and Intrinsic Oxidative Resistance for Enhanced Photodynamic Therapy.” ACS Nano, 14 (2020), 2183-2190. (IF: 15.881, 1区)

6.    Yuanbo Wang#, Leilei Shi# (Co-first author), Dou Ma, Shidang Xu, Wenbo Wu, Li Xu, Majid Panahandeh-Fard, Xinyuan Zhu, Bo Wang*, Bin Liu*, “Tumor-Activated and Metal–Organic Framework Assisted Self-Assembly of Organic Photosensitizers” ACS Nano, 14 (2020), 13056-13068. (IF: 15.881, 1区)

7.    Leilei Shi, Xihui Gao, Wangzhang Yuan, Li Xu, Hongping Deng, Chenwei Wu, Jiapei Yang, Xin Jin*, Chuan Zhang*, Xinyuan Zhu. “Endoplasmic Reticulum Targeting Fluorescent Nanodot with Large Stokes Shift for Vesicular Transport Monitoring and Long-Term Bioimaging.” Small, 25 (2018), e01800223. (IF: 13.281, 1区)

8.    Peng Zhang, Haizhu Kuang, Yingying Xu, Leilei Shi* (corresponding author), Weilin Cao, Kongkai Zhu*, Li Xu, Jing Ma*. “Rational Design of High Performance Quinoxalinone-Based AIE Photosensitizer for Image-Guided Photodynamic Therapy.” ACS Applied Materials & Interfaces, 12(2020), 42551-42557. (IF: 9.229, 1区)

9.    Leilei Shi, Li Xu, Chenwei Wu, Bai Xue, Xin Jin*, Jiapei Yang, Xinyuan Zhu, “Celecoxib Induced Self-assembly of Smart Albumin-Doxorubicin Conjugate for Enhanced Cancer Therapy.” ACS Applied Materials & Interfaces, 10 (2018), 8555-8565. (IF: 9.229, 1区)

10.  Ting Zhu#, Leilei Shi# (Co-first author), Chunyang Yu, Yabing Dong, Feng Qiu, Lingyue Shen, Qiuhui Qian, Guoyu Zhou*, Xinyuan Zhu*. “Ferroptosis Promotes Photodynamic Therapy: Supramolecular Photosentizer-Inducer Nanodrug for Enhanced Cancer Treatment.” Theranostics, 9 (2019), 3293-3307. (IF: 11.556, 1区)

11.  Leilei Shi, Qinghua Guan, Xihui Gao, Xin Jin, Li Xu, Jian Shen*, Chenwei Wu, Chuan Zhang*, Xinyuan Zhu. “Reaction Based Color-Convertible Fluorescent Probe for Ferroptosis Identification.” Analytical Chemistry, 90 (2018), 9218-9225. (IF: 6.986, 1区)

12.  Leilei Shi, Li Xu, Qinghua Guan, Xin Jin*, Jiapei Yang, Xinyuan Zhu, “Light-trigerred Cellular Epigenetic Molecule Release to Reverse Tumor Multi-drug Resistance”, Bioconjugate Chemistry, 29 (2018), 1344-1351. (IF: 4.774, 2区)

13.  Leilei Shi, Yi Hu, Ang Lin, Chuan Ma, Chuan Zhang*, Yue Su, Linzhou Zhou, Yumei Niu, Xinyuan Zhu*, “Matrix Metalloproteinase Responsive Nanoparticles for Synergistic Treatment of Colorectal Cancer via Simultaneous Anti-Angiogenesis and Chemotherapy”, Bioconjugate Chemistry, 27 (2016), 2943-2953. (IF: 4.774, 2区)

14.  Leilei Shi, Jianfeng Zhou, Jifeng Wu, Junya Cao, Yuemao Shen, Hua Zhou, Xun Li* “Quinoxalinone (Part II). Discovery of (Z)-3-(2-(pyridine-4-yl)vinyl) quinoxalinone derivates as potent VEGFR-2 kinase inhibitors”, Bioorganic & Medicinal Chemistry, 24 (2016), 1840-1852. (IF: 3.641, 3区)

15.  Leilei Shi, Jianfeng Zhou, Jifeng Wu, Yuemao Shen, Xun Li*, “Anti-Angiogenic Therapy: Strategies to Develop Potent VEGFR-2 Tyrosine Kinase Inhibitors and Future Prospect”, Current Medicinal Chemistry, 23 (2016), 1000-1040. (IF: 4.530, 3区)

16.  Leilei Shi, Wei Hu, Jifeng Wu, Huaiyu Zhou, Xun Li*, “Quinoxalinone as a Privileged Platform in Drug Development”, Mini-reviews in Medicinal Chemistry, 18 (2018), 392-413. (IF: 3.862, 3区)